Assembly Of High Order Gαq-Effector Complexes With RGS Proteins*
نویسندگان
چکیده
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA. Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. Chemical Biology Program, University of Michigan, Ann Arbor, MI 481091055, USA. Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-5632, USA. Current address: University of Iowa, College of Pharmacy, Iowa City, IA 52242-1112. Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
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The intracellular regulator of G protein signalling (RGS) proteins were first identified as GTPase activating proteins (GAPs) for heterotrimeric G proteins, however, it was later found that they can also regulate G protein-effector interactions in other ways that are still not well understood. There is increasing evidence that some of the effects of RGS proteins occur due to their ability to in...
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